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We also genotyped females and 62 males, cancer personalidade feminina formed the control group. Genotyping results were related to environmental risk factors, smoking habit and diet. Conclusions: In Romanians, the association between the mutated genotypes and environmental risk factors modulates the risk for sporadic CRC. Smoking in association with the ArgGln-XRCC1 genetic variation influences the early onset of sporadic colorectal cancer in females.

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Genotyping results were related to environmental risk factors, smoking habit and diet. A significantly increased risk for CRC was observed in females and males with high daily fried red meat intake, carriers of the ArgGln OR 2. Conclusions: In Romanians, the association between the mutated genotypes and environmental risk factors modulates the risk for sporadic CRC. Smoking in association with the ArgGln-XRCC1 genetic variation influences the early onset of sporadic colorectal cancer in females.

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